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The clinical manifestations of sickle cell anemia result from pathologic changes to structures and systems throughout the body.

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Introduction to Sickle Cell Anemia

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Sickle cell anemia (sickle cell disease) is a disorder of the blood caused by an inherited abnormal hemoglobin (the oxygen-carrying protein within the red blood cells). The abnormal hemoglobin causes distorted (sickled appearing under a microscope) red blood cells.