Male Reproductive System - The gonadotropin releasing hormone

• Hormonal mechanisms that influence male reproductive function involve endocrine tissues contained in the: • Hypothalamus of the brain. • Anterior pituitary. • Testes. • In the hypothalamus, certain neurosecretory cells secrete gonadotropin- releasing hormone (GnRH). • GnRH is carried by the blood to the anterior pituitary, where it binds to receptors on gonadotrophs. • GnRH then stimulates gonadotroph cells to increase secretion of two gonadotropic hormones: • Lutenizing hormone (LH). • Follicle-stimulating hormone (FSH). • LH and FSH are transported in the blood to the testes from the anterior pituitary. • LH and FSH both indirectly affect spermatogenesis. • LH binds to receptors on Leydig (interstitial) cells between seminiferous tubules and stimulates the secretion of testosterone. • Under the influence of FSH and testosterone, Sertoli cells produce Androgen-binding protein (ABP) that binds and maintains high testosterone levels near the spermatogenic cells.

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