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Renin/Angiotensin (water gain from urine & Na ion and water reabsorption)

By: HWC, Views: 7665

• Sensing declining blood pressure or blood volume, juxtaglomerular cells of the nephron release renin, an enzyme that promotes the formation of angiotensin II. • Angiotensin II targets smooth muscle cells in blood vessels that provide blood to the nephron. • Angiotensin II causes thes...

Regulation of GFR: autoregulation via tubuloglomerular feedback, neural & hormonal regulation

By: HWC, Views: 8914

• When blood pressure is above normal, rapid filtrate flow reduces ion retention so filtrate in tubule has more Na+, C1-, and water. • It is believed that vasoconstricting chemicals from the juxtaglomerular cells are released when the macula densa cells detect higher water and ion levels in ...

Regulation of GFR: autoregulation via myogenic mechanism Myogenic mechanism

By: HWC, Views: 9208

• GFR can be regulated by adjusting: • Blood flow in and out of the glomerular capillaries. • Surface area of glomerular capillaries. • There are three main ways to make these adjustments: • Renal autoregulation. • Nervous regulation. • Renal autoregulation occurs when...

Erythropoietin (EPO)

By: HWC, Views: 7240

■ Secreted by kidney cells when blood oxygen is low. ■ Targets cells in red bone marrow that will become red blood cells. ■ Promotes increased numbers of mature red blood cells. ■ More mature red blood cells carry more oxygen so blood oxygen level is restored to normal.

T cell receptors

By: HWC, Views: 7423

• T cells are responsible for cell-mediated immunity. • Each T cell contains a unique form of T cell receptor (TCR) on its membrane. • These T cell receptors are produced through a process of genetic recombination which is able to produce millions of different variations. • Each T ce...

Cytotoxic T cell receptors, activation, proliferation, differentiation & action

By: HWC, Views: 8052

• Most cells which have CD8 on their surface become cytotoxic T cells (Tc cells). • CD8 T cells recognize a foreign antigen when it is presented in conjunction with the protein, MHC-I. • Nearly all nucleated cells in the body express MHC-I molecules. • T cells that recognize self-pe...

Cardiac conductile cells

By: HWC, Views: 7982

• In order for the heart to function properly, all of its cells must contract in a specific sequence. This sequence is determined by a pathway known as the conduction system. • Cardiac muscle cells have two attributes that enable the conduction system to work: • Connective. Action pot...

Griffith's experiments

By: HWC, Views: 4877

In the late 1920s, Fred Griffith was attempting to develop a vaccine against a bacterium that causes pneumonia. To find out why two strains of the bacteria differed in their deadliness, he injected mice with four different mixtures. Mice injected with R cells remained healthy. When Griffith ex...

Cell mediated immune response to a viral infection Animation

By: HWC, Views: 3760

Intracellular pathogens are the targets of cell-mediated immune response. The process begins when a virus infects a macrophage. Another macrophage engulfs the same virus or an antigen from it. In both cells, enzymes cleave the viral antigens into small bits. The fragments move to the cell sur...