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Griffith's experiments

By: HWC, Views: 4878

In the late 1920s, Fred Griffith was attempting to develop a vaccine against a bacterium that causes pneumonia. To find out why two strains of the bacteria differed in their deadliness, he injected mice with four different mixtures. Mice injected with R cells remained healthy. When Griffith ex...

Regulation of GFR: autoregulation via tubuloglomerular feedback, neural & hormonal regulation

By: HWC, Views: 8916

• When blood pressure is above normal, rapid filtrate flow reduces ion retention so filtrate in tubule has more Na+, C1-, and water. • It is believed that vasoconstricting chemicals from the juxtaglomerular cells are released when the macula densa cells detect higher water and ion levels in ...

Mechanisms of capillary exchange

By: HWC, Views: 7891

■ The primary role of capillaries is to permit the exchange of nutrients and wastes between the blood and tissue cells (via interstitial fluid). ■ Oxygen and nutrients move from the blood to the cells. ■ Carbon dioxide and other wastes move from the cells to the blood. The three ba...

Introduction to filtration - filtrate formation and composition

By: HWC, Views: 7925

• At the nephron, the three process responsible for the formation of urine include: • Glomerular filtration. • Tubular reabsorption. • Tubular secretion. • During filtration, a filtrate is formed within the renal tubule. • Reabsorption is the conserving of water and many s...

Introduction to Pre-eclampsia

By: Administrator, Views: 10773

Pre-eclampsia (PE) is a disorder of pregnancy characterized by the onset of high blood pressure and often a significant amount of protein in the urine. When it arises, the condition begins after 20 weeks of pregnancy. In severe disease there may be red blood cell breakdown, a low blood platelet c...

Introduction to Insulin

By: Administrator, Views: 11841

The islets of Langerhans are composed of three major types of cells: Alpha cells secrete glucagon, elevating blood sugar. Beta cells secrete insulin, maintaining normal blood sugar. Delta cells secrete somatostatin, which suppresses release of glucagon and insulin. Hyposecretion or inadequa...

Mechanisms of capillary exchange (transcytosis & bulk flow)

By: HWC, Views: 7407

■ This method of capillary exchange is mainly used to transport small amounts of large, lipid-insoluble (water soluble) molecules, such as large proteins. ■ Substances, packaged in vesicles, move through endothelial cells via endocytosis and exocytosis. ■ This method of exchange is th...

Ventilation - phases and driving forces

By: HWC, Views: 7804

Respiration is the exchange of gases between the atmosphere, blood, and cells The combination of 3 processes is required for respiration to occur Ventilation (breathing) External (pulmonary) respiration Internal (tissue) respiration The cardiovascular system assists the respiratory system b...

Forming urine ( influencing factors), Forming dilute urine & Forming concentrated urine

By: HWC, Views: 8228

• The amount of urine produced by the nephron depends on : • Body fluid volume. • Body fluid composition. • Dilute urine is formed when the body is normally hydrated. • The medullary osmotic gradient determines the osmolarity of the filtrate. • Filtrate osmolarity increase...