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Cytotoxic T cell receptors, activation, proliferation, differentiation & action

By: HWC, Views: 8060

• Most cells which have CD8 on their surface become cytotoxic T cells (Tc cells). • CD8 T cells recognize a foreign antigen when it is presented in conjunction with the protein, MHC-I. • Nearly all nucleated cells in the body express MHC-I molecules. • T cells that recognize self-pe...

B cells and antibodies

By: HWC, Views: 8528

What Are Antibodies? Antibodies, also known as immunoglobulins, are Y-shaped proteins that are produced by the immune system to help stop intruders from harming the body. When an intruder enters the body, the immune system springs into action. These invaders, which are called antigens, can be vi...

Cardiac conductile cells

By: HWC, Views: 7990

• In order for the heart to function properly, all of its cells must contract in a specific sequence. This sequence is determined by a pathway known as the conduction system. • Cardiac muscle cells have two attributes that enable the conduction system to work: • Connective. Action pot...

Coaductile pathway, Timing of contraction signal & Conduction system and ECG

By: HWC, Views: 7945

• When the system is healthy, the signal to contract the entire conduction system originates in the SA node - known as the heart's pacemaker. • The SA node triggers contraction because it depolarizes at a faster rate than other parts of the conduction system. • The wave of excitation fr...

Depolarization of the SA node, Action potentials of the myocardium & ANS effects

By: HWC, Views: 7638

• A typical contractile cell in the myocardium has a resting membrane potential. • The resting membrane potential of cells in the SA node is not fixed, and is known as the pacemaker potential. • The action potential of a healthy SA nodal cell has three parts: • Pacemaker potential: ...

Five phases of cardiac cycle & Atrial contraction

By: HWC, Views: 7780

1. Atrial contraction (atrial systole). 2. Isovolumetric (ventricular) contraction. 3. Ventricular ejection. 4. Isovolumetric (ventricular) relaxation. 5. Passive ventricular filling. Beginning of cardiac cycle • Prior to atrial contraction: • Atria and ventricles are relaxed....

Electrical changes in the heart

By: HWC, Views: 7589

• ECG: Graph of the voltage changes that occur during the cardiac cycle. • Readings are taken by electrodes placed on the surface of the body. • Electrodes detect voltage changes caused by the electrical activity of the heart. • P wave = atrial excitation (atrial depolarization). ...

Isovolumetric VC, Ventricular ejection, Isovolumetric & Passive ventricular filling

By: HWC, Views: 7702

• Isovolumetric means that blood volume does not change. • Ventricular blood volume and cell length remain constant. • With valves closed and contraction continuing, ventricular pressure continues to rise. • Ventricular pressure rises above arterial pressure. • Increased ventr...

Heart sounds

By: HWC, Views: 7632

During a normal, healthy heartbeat, or what we call a cardiac cycle, the top two chambers of the heart, called the atria, contract simultaneously. Then, as they relax, the bottom two chambers, called the ventricles, contract. This explains what happens during a cardiac cycle, but what it doesn't ...