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Introduction to Sickle Cell Anemia

By: Administrator, Views: 11152

Sickle cell anemia (sickle cell disease) is a disorder of the blood caused by an inherited abnormal hemoglobin (the oxygen-carrying protein within the red blood cells). The abnormal hemoglobin causes distorted (sickled appearing under a microscope) red blood cells.

Structures that affect circulation - kidneys and blood volume and skeletal muscle pumping

By: HWC, Views: 8290

• Kidneys regulate blood volume and blood osmolarity via salt and water reabsorption. • Increased reabsorption increases blood volume and venous return (and CO). • Decreased reabsorption Increases urine production, which decreases blood volume and venous return (and CO). • Systemi...

Oxygen transport - methods and oxyhemoglobin

By: HWC, Views: 7537

• The blood is the medium used for gas transport throughout the body. • Oxygen is only available in the lungs. Because the partial pressure of oxygen is higher in the alveoli than in the blood, oxygen diffuses into the blood and is transported to systemic cells. • At the tissues the par...

Structures that affect circulation - arterioles and vasomotor responses

By: HWC, Views: 7425

■ Small arteries and arterioles determine SVR. ■ Blood pressure drops significantly as blood passes through arterioles. ■ Decreasing arteriole radius and decreased wall elasticity are the main reasons for increased SVR. ■ Small changes in arteriole radius can cause large changes in ...

Insulin (glucose uptake by body cells), glycogenesis and lipogenesis

By: HWC, Views: 7831

Insulin is the regulator that allows the sugar from the foods we eat (be it a piece of cake or a stick of celery) to enter our tissues and become part of the metabolic process. Insulin is made by the Islets of Langerhans, which are found in the pancreas of every person. As we previously mentio...

Parathyroid hormone (bone resorption) & Calcitonin (bone deposition)

By: HWC, Views: 7692

• Cellular needs for calcium may cause blood calcium concentrations to decline below the normal range. • This decrease stimulates cells in the parathyroid gland to secrete parathyroid hormone. • Binding of parathyroid hormone to osteoclasts in bone tissue promotes bone resorption and th...

Regulation of GFR: three methods, autoregulation & autoregulation via myogenic mechanism

By: HWC, Views: 8155

• GFR can be regulated by adjusting: • Blood flow in and out of the glomerular capillaries. • Surface area of glomerular capillaries. • There are three main ways to make these adjustments: • Renal autoregulation. • Nervous regulation. • Hormonal regulation. • Ren...

Dietary Cholesterol & LDL

By: HWC, Views: 7039

LDL comprises 60–70% of total blood lipoproteins and is responsible for carrying cholesterol particles throughout your body. Having a lot of cholesterol carried by LDL lipoproteins is associated with an increased risk of heart disease. In fact, the higher the level, the greater the risk. ...

Net filtration pressure and lymph formation, edema & blood velocity

By: HWC, Views: 7489

Bulk flow -net filtration pressure and lymph formation • The net filtration pressure (NFP) is the force promoting filtration minus the force promoting reabsorption. • At the arterial end of an ideal capillary, the filtration pressures are stronger. The result: net filtration. • At t...