Lipid digestion - mouth, stomach and small intestine

• Lipid digestion takes place primarily in the small intestine; some occurs in the mouth and stomach. • Lipases are enzymes that break down triglycerides and phospholipids. • Lingual and gastric lipases hydrolyze a small amount of triglycerides. • End products are fatty acids and monoglycerides. • In the duodenum, triglycerides interact with bile salts and pancreatic juice. • Bile salts cling to mono-, di-, and triglycerides of fat globules. • The breakup of the fat globules results in triglyceride emulsion droplets. • Pancreatic lipase: • Is produced by pancreatic acinar cells. • Attaches to triglyceride molecules of the emulsion droplets. • Catalyzes the break up of the triglyceride molecules into monoglycerides and fatty acids. • Breaks down most triglycerides in the duodenum of the small intestine.

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