Stroke volume - contractility definition
Date Uploaded: 01/27/2020
Contractility is the forcefulness of contraction of cardiac muscle. • Inotropic agents are substances that increase or decrease contractility (and stroke volume). • Positive inotropic agents increase contractility and will increase stroke volume and cardiac output. • Negative inotropic agents reduce force of contraction. • Positive inotropic agents include: • Neurotransmitters (norepinephrine). • Hormones (epinephrine and thyroxine). • Drugs (digoxin). • Negative inotropic agents reduce contractility and include: • Calcium channel blockers. • Some anesthetics.
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