Glucagon (glycogenolysis and gluconeogenesis)

• Exercise, or not having eaten recently, causes a decline in blood glucose concentration. • Low blood glucose stimulates alpha cells in the pancreatic islets to secrete glucagon. • Glucagon targets liver cells. • Glucagon causes liver cells to undergo: • Glycogenolysis, a process which breaks down glycogen into glucose. • Gluconeogenesis, a process which produces glucose from non-carbohydrate sources like amino acids and glycerol. • The glucose is released into the blood and blood glucose concentration is restored to normal levels.

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