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Introduction to Sickle Cell Anemia

By: Administrator, Views: 11152

Sickle cell anemia (sickle cell disease) is a disorder of the blood caused by an inherited abnormal hemoglobin (the oxygen-carrying protein within the red blood cells). The abnormal hemoglobin causes distorted (sickled appearing under a microscope) red blood cells.

Oxygen transport - methods and oxyhemoglobin

By: HWC, Views: 7537

• The blood is the medium used for gas transport throughout the body. • Oxygen is only available in the lungs. Because the partial pressure of oxygen is higher in the alveoli than in the blood, oxygen diffuses into the blood and is transported to systemic cells. • At the tissues the par...

Role of the urinary system - acidosis and alkalosis

By: HWC, Views: 7949

• Tubular cells of the proximal convoluted tubule and collecting tubules can alter filtrate pH and therefore blood pH. • These cells can affect blood pH with two coupled mechanisms: • Reabsorption of bicarbonate ions. • Secretion of hydrogen ions. • The reabsorption of bicarbonate...

Structures that affect circulation - arterioles and vasomotor responses

By: HWC, Views: 7425

■ Small arteries and arterioles determine SVR. ■ Blood pressure drops significantly as blood passes through arterioles. ■ Decreasing arteriole radius and decreased wall elasticity are the main reasons for increased SVR. ■ Small changes in arteriole radius can cause large changes in ...

Insulin (glucose uptake by body cells), glycogenesis and lipogenesis

By: HWC, Views: 7831

Insulin is the regulator that allows the sugar from the foods we eat (be it a piece of cake or a stick of celery) to enter our tissues and become part of the metabolic process. Insulin is made by the Islets of Langerhans, which are found in the pancreas of every person. As we previously mentio...

Parathyroid hormone (bone resorption) & Calcitonin (bone deposition)

By: HWC, Views: 7692

• Cellular needs for calcium may cause blood calcium concentrations to decline below the normal range. • This decrease stimulates cells in the parathyroid gland to secrete parathyroid hormone. • Binding of parathyroid hormone to osteoclasts in bone tissue promotes bone resorption and th...

Effect of blood chemistry - stimuli, hyperventilation response and hypoventilation response

By: HWC, Views: 7441

• Respiratory rate is effected by changes in: • Blood pH. • Blood Pco2. • Blood P02. • Chemoreceptors in the central and peripheral nervous systems closely monitor the Fr, CO2 and 02 levels in blood. • Changes in frequency of impulses from Chemoreceptors affect respiratory r...

Regulation of GFR: three methods, autoregulation & autoregulation via myogenic mechanism

By: HWC, Views: 8155

• GFR can be regulated by adjusting: • Blood flow in and out of the glomerular capillaries. • Surface area of glomerular capillaries. • There are three main ways to make these adjustments: • Renal autoregulation. • Nervous regulation. • Hormonal regulation. • Ren...

Dietary Cholesterol & LDL

By: HWC, Views: 7039

LDL comprises 60–70% of total blood lipoproteins and is responsible for carrying cholesterol particles throughout your body. Having a lot of cholesterol carried by LDL lipoproteins is associated with an increased risk of heart disease. In fact, the higher the level, the greater the risk. ...