Gastrin (gastric emptying) & Secretin (buffering gastric acid)

• Gastrin also binds to the smooth muscle cells in the stomach causing: • Increased gastric motility. • Opening of pyloric sphincter. • Increased gastric emptying. • The intestinal phase of digestion begins as chyme enters the duodenum. • The chyme's acidity can damage intestinal mucosa. • S cells in intestinal mucosa are stimulated to produce secretin. • Secretin targets pancreatic acinar cells. • Secretin stimulates the pancreas to produce and deliver more bicarbonate to the small intestine. • Bicarbonate buffers acidity of chyme and protects intestinal tissue.

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