Hormonal regulation of blood pressure - RAA system

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■ Long-term regulation of MABP is under hormonal control. • Hormones that affect blood pressure and volume: the renin-angiotensin-aldosterone (RAA) system, antidiuretic hormone (ADM), and atrial natriuretic peptide (ANP). ■ Most important hormonal regulator of MABP. Activated by drop in MABP. ■ Renin: Enzyme that promotes sequential formation of angiotensin from the plasma protein angiotensinogen. • Angiotensin converting enzyme (ACE): Acts with renin to convert angiotensin to angiotensin II. ■ Angiotensin II: Potent vasoconstrictor that increases SVR . • Angiotensin II targets smooth muscle cells in systemic arterioles. ■ Blood vessels constrict, increasing SVR, raising MABP back toward normal.

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